Pyridines and derivatives
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- (6)
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- (2)
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- (1)
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- (8)
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- (357)
- (2)
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- (1)
- (1)
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- (1)
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- (128)
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- (1)
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- (1)
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- (2)
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- (12)
- (1)
- (1)
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- (1)
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- (11)
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- (2)
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- (15)
- (1)
- (1)
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- (1)
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Filtered Search Results
Selleck Chemical LLC JQAD1-E1215-100MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Neuroligin-1 (mouse) recombinant protein, His tag | 500 UG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Recombinant mouse Neuroligin-1 is a glycosylated, His-tagged cell-surface protein expressed in HEK293 cells and supplied lyophilized for use in biochemical assays, antibody validation, and receptor interaction studies. Handle and store according to the manufacturer's datasheet for optimal stability.
- Species mouse
- Expression system HEK293
- His tag
- Molecular weight approximately 80-125 kDa (glycosylated)
- Formulation lyophilized from PBS, pH 7.4
- Endotoxin level <1 EU/μg (LAL)
- Storage store at -20°C; after reconstitution stable at 4°C for 1 week or -20°C for longer
- Reconstitution guidance do not reconstitute below 100 μg/mL in ddH2O
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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![Apexbio Technology LLC type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000093690.png-250.jpg)
Apexbio Technology LLC type I hair keratin fragment [Homo sapiens]/[Ovis aries]/[Rattus norvegicus] 5mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Type I hair keratin fragment is a protein fragment derived from acidic epithelial intermediate filament proteins It is not classified as a small-molecule inhibitor or agonist The fragment is primarily utilized as a molecular probe in studies evaluating antibody specificity and keratin filament assembly No direct target mechanism of action or activity metrics have been specified Based on its properties type I hair keratin fragment holds research potential as a biomarker candidate in dermatological research and keratinization disorders
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Selleck Chemical LLC Anti-CD47-A2637-1MG-5
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Anti-CD47 is a humanized monoclonal antibody (mAb) targeting CD47 It can be used for the research of hematologic malignancies and solid tumors MW 150 KD
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Ambeed Dichloro 1 3bis 2 6Di3pentylph
Dichloro[1,3-bis(2,6-Di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II), 1158652-41-5, 98%
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TARGETMOL CHEMICALS INC dUTP trisodium 50MG
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Also available in 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR. Purity 100%
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000698523 PROTAC CHK1 DEGRADER 100MG
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Apexbio Technology LLC BIX 01294 935693-62-2 5mg
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BIX 01294 (CAS 935693-62-2) is a small molecule inhibitor identified through high-throughput screening of a synthetic compound library for its activity against G9a and GLP both H3K9-specific histone lysine methyltransferases BIX 01294 shows selectivity for G9a and GLP relative to other methyltransferases such as SUV39H1 ESET SET7/9 and the arginine methyltransferase PRMT1 Structural studies demonstrate that BIX 01294 binds to the histone peptide-binding pocket of GLP rather than the lysine channel In cell-based assays treatment with BIX 01294 at 4 1 M reduces levels of H3K9 dimethylation while higher concentrations induce cytotoxicity This compound is widely used as a chemical probe in studies of epigenetic regulation and gene expression
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Medchemexpress LLC Mardepodect | 898562-94-2 | 98.8% | C25H20N4O | 25 MG
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Mardepodect (PF-2545920) is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, demonstrating over 1000-fold selectivity over other PDEs. It has shown activity in preclinical models for positive, cognitive, and negative symptoms of schizophrenia and increases striatal cGMP in mice in a dose-dependent manner. This product is for research use only.
- Potent and selective PDE10A inhibitor
- Orally active and brain-penetrant
- IC50 of 0.37 nM
- Exhibits >1000-fold selectivity over other PDEs
- Active in conditioned avoidance response (CAR) assay with an ED50 of 1 mg/kg
- Causes a dose-dependent increase in striatal cGMP in mice
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Medchemexpress LLC NS1643 | 448895-37-2 | 99.04% | 380.24 | 25 MG
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NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. It inhibits the growth of breast cancer tumors in TNBC mouse models and also inhibits cell migration and invasion of breast cancer cells.
- Partial agonist of hERG K+ channels (EC50 of 10.5 μM)
- Inhibits breast cancer tumor growth in TNBC mouse models
- Inhibits cell migration and invasion of breast cancer cells
- Dose- and voltage-dependently increases hERG current in oocytes
- Slows the rate of hERG inactivation and reduces hERG channel rectification
- Decreases Vimentin, N-cadherin, and CD44 levels, and increases E-cadherin in breast cancer cell lines (MDA-MB-231, SKBR3, and MCF7)
- Inhibits breast tumor metastasis in NSG mice with human-derived TNBC tumor xenografts
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eMolecules 4934-99-0 | Methyl 3-hydroxycyclobutanecarboxylate | ChemScene | MFCD00512755 | 130.143 | C6H10O3 | 97.000 | COC(=O)C1CC(O)C1 | 100g | 596090450
Methyl 3-hydroxycyclobutanecarboxylate | ChemScene | 4934-99-0 | MFCD00512755 | 130.143 | C6H10O3 | 97.000 | COC(=O)C1CC(O)C1 | 100g | 596090450
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Medchemexpress LLC Stepronin (Prostenoglycine) | 72324-18-6 | 99.5% | C10H11NO4S2 | 100 MG
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Stepronin (Prostenoglycine) is an orally active expectorant, though inhalation administration is preferred over oral administration. It functions by inhibiting airway secretion in vitro, specifically by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucal glands.
- Orally active expectorant
- Inhibits airway secretion in vitro
- Reduces Cl- secretion from epithelial cells
- Reduces mucus glycoprotein secretion from submucal glands
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Medchemexpress LLC Irilone | 41653-81-0 | 298.25 | 5 MG
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Irilone is a flavonoid compound that can be isolated from the flowers and leaves of red clover (Trifolium pratense).
- Type of flavonoid.
- Can be isolated from the flowers and leaves of red clover (Trifolium pratense).
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Medchemexpress LLC 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxopyrrolo[3,2-e]indole dicarboxylate | 2304465-89-0 | C26H17ClN2O8S | 5 MG
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F5446 is a selective small molecule inhibitor of SUV39H1 methyltransferase. It decreases H3K9me3 deposition at the FAS promoter, increases Fas expression, and enhances colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. This compound also suppresses human colon tumor xenograft growth in vivo.
- Selective SUV39H1 methyltransferase inhibitor
- Decreases H3K9me3 deposition at the FAS promoter
- Increases Fas expression
- Enhances colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro
- Suppresses human colon tumor xenograft growth in vivo
- Induces apoptotic cell death in SW620 and LS411N cells
- Up-regulates tumor cell surface Fas expression
- Induces human colon tumor cell cycle arrest and apoptosis
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Aobchem AOBCHEM
5001039079 1-CHLORO-2-ISOPROPOXY-3 5-DIME
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